Loss of Resistin Improves Glucose Homeostasis in Leptin Deficiency

来自 EBSCO

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作者：

Y Qi，Z Nie，YS Lee，NS Singhal，PE Scherer，MA Lazar，RS Ahima

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摘要：

Resistin levels are increased in obesity, and hyperresistinemia impairs glucose homeostasis in rodents. Here, we have determined the role of resistin in mice that are obese and insulin resistant because of genetic deficiency of leptin. Loss of resistin increased obesity in mice by further lowering the metabolic rate without affecting food intake. Nevertheless, resistin deficiency improved glucose tolerance and insulin sensitivity in these severely obese mice, largely by enhancing insulin-mediated glucose disposal in muscle and adipose tissue. In contrast, in C57BL/6J mice with diet-induced obesity but wild-type leptin alleles, resistin deficiency reduced hepatic glucose production and increased peripheral glucose uptake. Resistin deficiency enhanced Akt phosphorylation in muscle and liver and decreased suppressor of cytokine signaling-3 level in muscle, and these changes were reversed by resistin replacement. Together, these results provide strong support for an important role of resistin in insulin resistance and diabetes associated with genetic or diet-induced obesity.

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关键词：

Homeostasis

DOI：

10.2337/db05-0615

被引量：

368

年份：

2006