Control of Early Viral and Bacterial Distribution and Disease by Natural Antibodies
摘要：
Natural antibodies are often dismissed from immunological analysis as "background," but they may play an important role in conferring immunity against infections. In antibody-free mice infected with various viruses or with Listeria monocytogenes, viral or bacterial titers in peripheral organs, including the kidney and brain, were 10 to 100 times greater than in antibody-competent mice (and enhanced their susceptibility to some infections), and titers in secondary Lymphoid organs were 10 to 100 times lower than in antibody-competent mice. Thus, natural antibodies play a crucial role by preventing pathogen dissemination to vital organs and by improving immunogenicity through enhanced antigen-trapping in secondary Lymphoid organs.
展开
关键词：
Animals Mice, Inbred C57BL Mice Lymphoid Tissue Spleen Kidney Listeria monocytogenes Vaccinia virus Lymphocytic choriomeningitis virus Virus Diseases
DOI：
10.1126/science.286.5447.2156
被引量：
年份：
1999
BMJ
万方医学
Semantic Scholar
dx.doi.org
Cell Press
查看更多
NCBI
Oxford Univ Press
NCBI
Europe PMC
JSTOR
JBC
NRC Research Press
dialnet.unirioja.es
ResearchGate
ProQuest
EBSCO
science-open.com
readcube.com
emboj.embopress.org
highbeam.com
scienceopen.com
pubget.com
jem.rupress.org
jb.asm.org
nejm.org
jneuroinflammation.com
jlr.org
mct.aacrjournals.org
jleukbio.org
jimmunol.org
sciencemag.org
elifesciences.org
www.socolar.com
onAcademic
mendeley.com
ganino.com
(全网免费下载)
ganino.com
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
