Role of IRS-2 in insulin and cytokine signalling
摘要：
THE protein IRS-1 acts as an interface between signalling proteins with Src-homology-2 domains (SH2 proteins) and the receptors for insulin, IGF-1, growth hormone, several interleukins (IL-4, IL-9, IL-13) and other cytokines 1–7 . It regulates gene expression and stimulates mitogenesis and appears to mediate insulin/1GF-1-stimulated glucose transport 8 . Thus, survival of the IRS-1 7 mouse with only mild resistance to insulin was surprising9'10. This dilemma is provisionally resolved with our discovery of a second IRS-signalling protein. We purified and cloned a likely candidate called 4PS from myeloid progenitor cells and, because of its resemblance to IRS-1, we designate it IRS-2. Alignment of the sequences of IRS-2 and IRS-1 revealed a highly conserved amino terminus containing a pleckstrin-homology domain and a phos-photyrosine-binding domain and a poorly conserved carboxy terminus containing several tyrosine phosphorylation motifs. IRS-2 is expressed in many cells, including tissues from IRS-1 / mice 11 and may be essential for signalling by several receptor systems.
展开
DOI：
10.1038/377173a0
被引量：
年份：
1995
Nature
Nature
(全网免费下载)
EBSCO
万方医学
万方医学
查看更多
掌桥科研
dx.doi.org
Cell Press
NCBI
Oxford Univ Press
Europe PMC
NCBI
AACR
JBC
adsabs.harvard.edu
ProQuest
ResearchGate
EureKaMag.com
(全网免费下载)
EBSCO
EBSCO
science-open.com
ftp.palgrave-journals.com
mcb.asm.org
molbiolcell.org
whitelabs.org
(全网免费下载)
jcb.rupress.org
jneurosci.org
circ.ahajournals.org
press.endocrine.org
diabetes.diabetesjournals.org
ukpmc.ac.uk
jimmunol.org
stke.sciencemag.org
embojnl.embopress.org
jme.endocrinology-journals.org
bprcem.com
plantphysiol.org
onAcademic
cghjournal.org
readcube.com
jap.physiology.org
jasn.asnjournals.org
jleukbio.org
jn.nutrition.org
deepdyve.com
jacionline.org
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
