Modeling coincidence detection in nucleus laminaris

来自 EBSCO

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摘要：

A biologically detailed model of the binaural avian nucleus laminaris is constructed, as a two-dimensional array of multicompartment, conductance-based neurons, along tonotopic and interaural time delay (ITD) axes. The model is based primarily on data from chick nucleus laminaris. Typical chick-like parameters perform ITD discrimination up to 2 kHz, and enhancements for barn owl perform ITD discrimination up to 6 kHz. The dendritic length gradient of NL is explained concisely. The response to binaural out-of-phase input is suppressed well below the response to monaural input (without any spontaneous activity on the opposite side), implicating active potassium channels as crucial to good ITD discrimination.

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关键词：

Theoretical or Mathematical/ biocybernetics biology computing biomembrane transport neurophysiology potassium/ modeling coincidence detection binaural avian nucleus laminaris biologically detailed model two-dimensional array conductance-based neuron interaural time delay chick-like parameter barn owl perform monaural input spontaneous activity active potassium channel nucleus laminaris nucleus magnocellularis interaural time difference best frequency 2 kHz 6 kHz K/ A8710 General, theoretical, and mathematical biophysics A8725D Biological transport cellular and subcellular transmembrane physics A8730 Biophysics of neurophysiological processes A8725 Cellular biophysics C7330 Biology and medical computing / frequency 2.0E+03 Hz frequency 6.0E+03 Hz/ K/el