Noninvasive diagnostic assessment of brain tumors using combined in vivo MR imaging and spectroscopy

来自 EBSCO

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作者：

D Galanaud，F Nicoli，O Chinot，S Confort-Gouny，D Figarella-Branger，P Roche，S Fuentès，YL Fur，JP Ranjeva，PJ Cozzone

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摘要：

To determine the potential value of multimodal MRI for the presurgical management of patients with brain tumors, we performed combined magnetic resonance imaging (MRI) and proton MR spectroscopy (MRS) in 164 patients who presented with tumors of various histological subtypes confirmed by surgical biopsy. Univariate statistical analysis of metabolic ratios carried out on the first 121 patients demonstrated significant differences in between-group comparisons, but failed to provide sufficiently robust classification of individual cases. However, a multivariate statistical approach correctly classified the tumors using linear discriminant analysis (LDA) of combined MRI and MRS data. After initial separation of contrast-enhancing and non-contrast-enhancing lesions, 91% of the former and 87% of the latter were correctly classified. The results were stable when this diagnostic strategy was tested on the additional 43 patients included for validation after the initial statistical analysis, with over 90% of correct classification. Combined MRI and MRS had superior diagnostic value compared to MRS alone, especially in the contrast-enhancing group. This study shows the clinical value of a multivariate statistical analysis based on multimodal MRI and MRS for the noninvasive evaluation of intracranial tumors. Magn Reson Med, 2006. 2006 Wiley-Liss, Inc.

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关键词：

Experimental/ biomedical MRI brain cancer image enhancement magnetic resonance spectroscopy neurophysiology statistical analysis surgery tumours/ noninvasive diagnostic assessment brain tumors in vivo MR imaging potential value multimodal MRI presurgical management magnetic resonance imaging proton MR spectroscopy surgical biopsy univariate statistical analysis metabolic ratio linear discriminant analysis LDA diagnostic strategy initial statistical analysis diagnostic value contrast-enhancing group multivariate statistical analysis noninvasive evaluation intracranial tumors/ A8760I Medical magnetic resonance imaging and spectroscopy A8740 Biomagnetism A8770E Patient diagnostic methods and instrumentation A8770G Patient care and treatment A8730 Biophysics of neurophysiological processes A0250 Probability theory, stochastic processes, and statistics B7510N Biomedical magnetic resonance imaging and spectroscopy B7520 Patient care and treatment B0240 Probability and statistics