Impact of new technologies for cellular screening along the drug value chain
摘要：
High-information screening formats, using more physiologically relevant cellular models and readout approaches, are slowly replacing traditional, target-orientated approaches in drug discovery programs. With improved access to primary cells, as well as label-free, non-intrusive methods of compound interrogation (such as automated electrophysiology), high-thoughput screening facilities have to adapt to more complex assay scenarios. The implementation of novel cellular systems, readout technologies and data management in a drug discovery company are essential to improve the current falling productivity evident in recent years throughout the pharmaceutical industry.
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关键词：
angiogenesis cancer age-related macular degeneration anti-angiogenic agents coumarin derivatives
DOI：
10.1016/j.drudis.2010.02.010
被引量：
年份：
2010
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