Re: CYP2D6 Genotype and Tamoxifen Response in Postmenopausal Women With Endocrine-Responsive Breast Cancer: The Breast International Group 1-98 Trial.
摘要：
The author discusses a study by M. M. Regan et al on CYP2D6 genotype and tamoxifen response in postmenopausal women with breast cancer. He suggests the serious doubts about conclusions raised by the implausible CYP2DC6 genotyping results from the Breast International Group 1-98 trial. He notes that the area representative of the invasive tumor component should have been avoided in the study. He also cites the lack of genotype data to evaluate the methodological problems that occurred.
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DOI：
10.1093/jnci/djs305
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2012
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