Bloom's syndrome. IV. Sister-chromatid exchanges in lymphocytes.
摘要：
An abnormally great amount of exhange between both sister and nonsister-but-homologous chromatids is a highly characteristic feature of cultured blood lymphocytes from individuals with Bloom's syndrome. However, a population of lymphocytes which exhibit a normal amount of exchange can be detected in the blood of some individuals with this syndrome. This coexistence of cells with a greatly increased number of sister-chromatid exchanges and others with a normal number results in a phenotypic dimorphism, in apparent contradiction to the autosomal recessive mode of inheritance of the syndrome.
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关键词：
Lymphocytes Chromosomes Humans Dwarfism Telangiectasis Facial Dermatoses Chromosome Aberrations Azure Stains Genes, Recessive Adult
被引量：
年份：
1977
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