Neurotoxins and Drugs for the Treatment of Parkinson's Disease. Part I: Neurotoxins, Levodopa, and Agents Influencing Dopamine Metabolism (A Review)
摘要：
This is the first part of a review devoted to xenobiotics involved in the pathogenesis of Parkinson's disease (PD) and to modern antiparkinsonian agents. Experimental and epidemiological evidence indicates that neurotoxins, in particular, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine ( MPTP ), can induce the degeneracy of dopamine neurons in the substantia nigra. The administration of levodopa ( L -dihydroxyphenylalanine, L -DOPA), a dopamine precursor and key drug for the treatment of PD, is associated with numerous side effects. For this reason, it is expedient to study and develop (i) inhibitors of enzymes converting levodopa into dopamine and (ii) agents influencing the release and trapping of the mediator.
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DOI：
10.1007/s11094-006-0001-2
被引量：
年份：
2005
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