Mitochondrial reactive oxygen species at the heart of the matter: new therapeutic approaches for cardiovascular diseases.
摘要：
Reactive oxygen species (ROS) have been implicated in a variety of age-related diseases, including multiple cardiovascular disorders. However, translation of ROS scavengers (antioxidants) into the clinic has not been successful. These antioxidants grossly reduce total levels of cellular ROS including ROS that participate in physiological signaling. In this review, we challenge the traditional antioxidant therapeutic approach that targets ROS directly with novel approaches that improve mitochondrial functions to more effectively treat cardiovascular diseases. 2015 American Heart Association, Inc.
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关键词：
mitochondria mitochondrial degradation mitochondrial dynamics protein kinase C reactive oxygen species
DOI：
10.1161/CIRCRESAHA.116.305432
被引量：
年份：
2015
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