摘要：

The recent development on the preparation of optically active ethyl-3-hydroxybutyrate(EHB) by microbial whole-cells was reviewed.Several measures for controlling the stereo-selectivity of the asymmetric reduction of ethyl acetoacetate(EAA) to EHB,such as concentration of substrate,selection of co-substrate and additives,gene engineering were also presented.The prospect of industrial preparation of the optically active EHB by microbial whole-cells was also discussed.

展开