Pd(II)-catalyzed ortho- or meta-C-H olefination of phenol derivatives.
摘要：
A combination of weakly coordinating auxiliaries and ligand acceleration allows for the development of both ortho- and meta-selective C-H olefination of phenol derivatives. These reactions demonstrate the feasibility of directing C-H functionalizations when functional groups are distal to target C-H bonds. The meta-C-H functionalization of electron-rich phenol derivatives is unprecedented and orthogonal to previous electrophilic substitution of phenols in terms of regioselectivity. These methods are also applied to functionalize α-phenoxyacetic acids, a fibrate class of drug scaffolds.
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关键词：
alkenes (benzene compounds C‐C bond formation monovalent phenols catalysis, phase‐transfer catalysis
DOI：
10.1021/ja400659s
被引量：
年份：
2013
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