Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors
摘要：
The primary structure of the receptor for platelet-derived growth factor (PDGF), determined by means of cloning a cDNA that encodes the murine pre-PDGF receptor, is closely related to that of the v-kit oncogene product and the receptor for macrophage colony stimulating factor (CSF-1). Common structural features include the presence of long sequences that interrupt the tyrosine-specific protein kinase domains of each molecule. The PDGF and CSF-1 receptors also share a characteristic distribution of extracellular cysteine residues. Ubiquitin is covalently bound to the purified PDGF receptor, the human gene for which is on chromosome 5.
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关键词：
Animals Humans Mice Chromosomes, Human, Pair 5 DNA Receptors, Platelet-Derived Growth Factor Platelet-Derived Growth Factor Receptors, Cell Surface Cloning, Molecular Base Sequence
DOI：
10.1038/323226a0
被引量：
年份：
1986
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