New molecular insights into CETP structure and function: a review.
摘要：
Cholesteryl ester transfer protein (CETP) is important clinically and is the current target for new drug development. Its structure and mechanism of action has not been well understood. We have combined current new structural and functional methods to compare with relevant prior data. These analyses have led us to propose several steps in CETP's function at the molecular level, in the context of its interactions with lipoproteins, e.g., sensing, penetration, docking, selectivity, ternary complex formation, lipid transfer, and HDL dissociation. These new molecular insights improve our understanding of CETP's mechanisms of action.
展开
关键词：
molecular biology of CETP functional domains of CETP lipid transfer biology lipid transfer tunnel hypothesis
DOI：
10.1194/jlr.R027011
被引量：
年份：
2012
NCBI
(全网免费下载)
Europe PMC
(全网免费下载)
American Society for Biochemistry and Molecular Biology
(全网免费下载)
钛学术
(全网免费下载)
jlr.org
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
引用走势
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
