Modification of narrow-spectrum peptidomimetic polyurethanes with fatty acid chains confers broad-spectrum antibacterial activity
摘要：
Each year, thousands of patients die from antimicrobial-resistant bacterial infections that fail to respond to conventional antibiotic treatment. Antimicrobial polymers are a promising new method of combating antibiotic-resistant bacterial infections. We have previously reported the synthesis of a series of narrow-spectrum peptidomimetic antimicrobial polyurethanes that are effective against Gram-negative bacteria, such as Escherichia coli; however, these polymers are not effective against Gram-positive bacteria, such as Staphylococcus aureus. With the aim of understanding the correlation between chemical structure and antibacterial activity, we have subsequently developed three structural variants of these antimicrobial polyurethanes using post-polymerization modification with decanoic acid and oleic acid. Our results show that such modifications converted the narrow-spectrum antibacterial activity of these polymers into broad-spectrum activity against Gram-positive species such as S. aureus, however, also increasing their toxicity to mammalian cells. Mechanistic studies of bacterial membrane disruption illustrate the differences in antibacterial action between the various polymers. The results demonstrate the challenge of balancing antimicrobial activity and mammalian cell compatibility in the design of antimicrobial polymer compositions. (c) 2019 Society of Chemical Industry
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关键词：
antimicrobial polymer Gram-negative bacteria Gram-positive bacteria polyurethanes membrane permeability
年份：
2019
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