摘要：

A new sesquiterpene quinone, 21-dehydroxybolinaquinone (5), together with two known related analogues, bolinaquinone (6) and dysidine (7), had been isolated from the Hainan sponge Dysidea villosa. The structure of the new compound 5 was elucidated on the basis of detailed analysis of spectroscopic data and by comparison with related model compounds. Compounds 5–7 were evaluated for the inhibitory activity against hPTP1B, a potential drug target for treatment of type-II diabetes and obesity, and cytotoxic activity against Hela cell line. The results showed that dysidine (7) had the strongest hPTP1B inhibitory activity with an IC50 value of 6.70 μM and 6 had significant cytotoxic activity against Hela cell line with an IC50 value of 5.45 μM. New compound 5 showed moderate PTP1B inhibitory activity and cytotoxicity with IC50 values of 39.50 and 19.45 μM, respectively.

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