Presynaptic calcium currents and their relation to synaptic transmission: Voltage clamp study in squid giant synapse and theoretical model for the calcium gate
摘要：
A voltage clamp study of the presynaptic terminal in squid stellate ganglion has given quantitative results relating inward Ca2+current to presynaptic membrane potential and postsynaptic response to inward Ca2+current. The results indicate an S-shaped curve for the relationship between presynaptic potential and Ca2+current and a linear relationship between Ca2+current and postsynaptic potential. A similar S-shaped curve was found for the time-dependent properties of the Ca2+conductance. Based on these results a mathematical model was developed which accounts for the experimental results in this and previously published papers by other authors. The model suggests that five subunits are involved in the Ca2+gate and that the subunits change noncooperatively from an inactive to an active form upon membrane depolarization.
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DOI：
10.1073/pnas.73.8.2918
被引量：
年份：
1976
掌桥科研
万方医学
Semantic Scholar
dx.doi.org
Europe PMC
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