摘要：

The present invention discloses a method for preparing a fat-soluble vitamin freeze-dried powder, comprising the steps of: (a) formulation process; (b) in accordance with a certain sequence added to the main drug, mixing; (c) to take vitamin D and the remaining amount stir after Tween 80, and (b) the mixture of step merger; (d) the water temperature controlled at 2-8 ℃, propylene glycol was added with stirring to dissolve, spare; (e) mixing two kinds of stock solution to adjust pH6. 7-7.2, adding activated carbon adsorption, carbon removal, fine filtration packing; (f) freeze-drying, freeze-drying curve: pre-freeze of -40 ℃ for 3 hours; sublimation stage, warmed to -15 ℃, and kept 10 hours, keeping indoor pressure 10-20Pa; after sublimation was complete, the product was raised to 5-8 ℃ for 10 hours; (g) after completion of vacuum freeze-dried tamponade. The method of the present invention is to ensure the stability of the main components of the drug, to improve product quality. At the same time by reducing the type and amount of materials used, it can also avoid all kinds of materials brought unexpected side effects.

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