is biologically active
摘要：
A human leukocyte interferon cDNA was enzymatically synthesized, inserted into the vector pBR322, and cloned in. The DNA sequence codes for a 23-amino acid signal peptide followed by an interferon polypeptide of 165 amino acids. An expression plasmid was constructed which permits the synthesis inof 2.5 x 10units of interferon per litre of culture. This LeIF protected squirrel monkeys from lethal encephalomyocarditis virus infection.
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关键词：
Humans Leukocytes Escherichia coli DNA, Recombinant Protein Precursors Interferons Cloning, Molecular Plasmids Amino Acid Sequence
DOI：
10.1038/287411a0
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