摘要：

Nine diorganotin(IV)compounds of Schiff bases derived from salicylaldehyde/substituted salicylaldehyde and thiosemicarbazide were synthesized.The compounds,with general formulae[R2Sn(OArCH=N-N=CSNH2)],where R=Me,n-Bu,Ph and Ar=-C6H4,-C6H3(5-Cl),-C6H3(5-Br),were characterized by UV and IR spectroscopy,NMR(~1H,~(13)C and ~(119)Sn)spectroscopy and elemental analysis.X-ray crystallographic studies of five of these complexes indicate penta-coordination of tin within a distorted C2NOS trigonal bipyramidal geometry in each case.The crystal packing in four of the structures features {…N-C-N-H}2 synthons,but in[Ph2Sn(OArCH=N-N=CSNH2)]the {…S-C-N-H}2 synthon is predominant.The biological activity of these compounds against four fungal pathogens(Curvularia eragrostidis,Altemaria porri,Dreschlerea oryzae and Macrophomina phaseolina)of four different crops(Camellia sineusis,Guizotia abyssinica,Oryzae sativa and Solatium melongena)and some bacteria(Aeromonas hydrophila,Salmonella typhi,Salmonella typhimurium,Salmonella flexnri,Escheria coli,Salmonella aureus,Bacillus subtilis and Lactobacillus rhamnosus)were investigated.Their cytotoxicity was also investigated against several human cancer cell lines.

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