摘要：

In current scenario transdermal delivery of bioactive molecules has become an interesting research area. Transdermal delivery enables direct entry of bioactive molecules into systemic circulation, bypass of hepatic metabolism, improves patient compliance, and low risk of injury to the tissues. Though it is one of the attractive routes, transport of drug through the skin has remained a challenge. To overcome the challenge, vesicular system has been adopted so as to have better skin permeation of bioactive agents. Vesicular system like liposome has shown inefficiency to cross the layers of skin. To overcome this hurdle a novel vesicular & non-invasive drug delivery system Nanoethosomes was developed. Nanoethosomes are used for deeper permeation of bioactive molecules. The main components are phospholipids, ethanol, and water. Presence of high amount of ethanol in their structure differentiates them from other vesicular systems and also helps to release encapsulated material into basal skin layer and blood circulation. Ethanol gives a net negative charge on vesicle surface promoting its size reduction. Vesicular system gives a better patient compliance, being a non-invasive method of drug administration. In this review article we are going to see brief information about methods of preparation, characterization and pharmaceutical uses of Nanoethosomes.

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