Rapamycin inhibits smooth muscle cell migration
摘要：
Rapamycin is a potent immunosuppressant that binds to the cytosolic protein, FKBP12, and blocks T cell activation. Here we report that rapamycin also blocks myogenic proliferation and induces differentiation, associated with a decrease in p34cdc2 activity and cyclin A levels. In yeast and mammals, rapamycin blocks cell cycle progression by causing G1 arrest, arguing for a conserved signaling...
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关键词：
Animals Humans Rats Muscle, Smooth Aorta Cells, Cultured Polyenes Sirolimus Tacrolimus Binding Proteins RNA
DOI：
10.1172/JCI119038
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年份：
1996
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