摘要：

A highly stereoselective synthesis of (+)-muscarine iodide has been achieved in eight steps and 20% overall yield from commercially available (S)-gamma-hydroxymethyl-gamma-butyrolactone.Few natural products have enjoyed the prominence of the alkaloid (+)-muscarine (1,X = OH or halogen,Scheme 1) in terms of history,biological activity,and impact to modern pharmacology and drug design.Interest in the muscarinic field has been invigorated in recent years with the discovery that potent muscarinic agonists,such as 1,could alleviate the short memory loss exhibited by Alzheimer's disease (AD) patients.

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