Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
申请(专利)号：
US11364061
申请日期：
20060228
公开/公告号：
US20060153801A1
公开/公告日期：
20060713
申请(专利权)人：
Nnochiri N. Ekwuribe
被引量：
摘要：
A non-polydispersed mixture of conjugates in which each conjugate in the mixture comprises a drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may exhibit higher in vivo activity than a polydispersed mixture of similar conjugates. The mixture may be more effective at surviving an in vitro model of intestinal digestion than polydispersed mixtures of similar conjugates. The mixture may result in less inter-subject variability than polydispersed mixtures of similar conjugates.
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