Redox-activated, hypoxia-selective DNA cleavage by quinoxaline 1,4-di-N-oxide

阅读量:

49

作者:

B GanleyG ChowdhuryJ BhansaliJS DanielsKS Gates

展开

摘要:

Quinoxaline 1,4-dioxide () is the historical prototype for modern heterocyclic -oxide antitumor agents such as 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine, ) and 3-amino-2-quinoxalinecarbonitrile 1,4-dioxide (). Early experiments in bacterial cell lines suggested that enzymatic, single-electron reduction of quinoxaline 1,4-dioxides under low-oxygen (hypoxic) conditions leads to DNA damage. Here the ability of quinoxaline 1,4-dioxide to cleave DNA has been explicitly characterized using in vitro assays. The hypoxia-selective DNA-cleaving properties of reported here may provide a chemical basis for understanding the cytotoxic and mutagenic activities of various quinoxaline 1,4-dioxide antibiotics.The hypoxia-selective DNA-cleaving properties of quinoxaline 1,4-dioxide reported here may provide a chemical basis for understanding the cytotoxic and mutagenic activities of this compound as well as and other substituted quinoxaline 1,4-dioxide antibiotics.

展开

DOI:

10.1016/S0968-0896(01)00163-8

被引量:

235

年份:

2001

通过文献互助平台发起求助,成功后即可免费获取论文全文。

相似文献

参考文献

引证文献

研究点推荐

引用走势

2013
被引量:34

辅助模式

0

引用

文献可以批量引用啦~
欢迎点我试用!

引用