bax-induced cytochrome c release from mitochondria is independent of the permeability transition pore but highly dependent on mg 2 ions
摘要:
Presents the results of a study which revealed that Bax, a pore-forming, mitochondria-associated protein contributes to the release of cytochrome C, which is facilitated by Mg2+ ions. Role of the Bcl-2 family in cell death; Release of cytochrome C during apoptosis; Details on the existence of two distinct mechanism leading to cytochrome C release; Factors which contribute to the leakage of cytochrome C from the mitochondria into the cytosol.
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DOI:
10.1083/jcb.143.1.217
年份:
2019
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来源期刊
Journal of Cell Biology
2019-03-04
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