bax-induced cytochrome c release from mitochondria is independent of the permeability transition pore but highly dependent on mg 2 ions

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23

摘要:

Presents the results of a study which revealed that Bax, a pore-forming, mitochondria-associated protein contributes to the release of cytochrome C, which is facilitated by Mg2+ ions. Role of the Bcl-2 family in cell death; Release of cytochrome C during apoptosis; Details on the existence of two distinct mechanism leading to cytochrome C release; Factors which contribute to the leakage of cytochrome C from the mitochondria into the cytosol.

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DOI:

10.1083/jcb.143.1.217

年份:

2019

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