摘要：

Microglia,a type of glial cells that play a role in the damage and repair of the central nervous system( CNS),is the most important immune defense of the central nervous system. Previous studies have shown that activated microglia participates in the onset and process of a series of neurodegenerative diseases in a direct or indirect way. In the pathological condition of Alzheimer's disease( AD),β-amyloid protein and a variety of proinflammatory factors stimulate and activate microglia,which results in the secretion of a variety of inflammatory factors and neurotoxins,leading to neuronal damages and even apoptosis,then triggering AD. Microglia can protect the central nervous system by phagocytosis and synaptic stripping. In this review,the roles of microglia in the process of AD neuroinflammation was summarized to provide the theoretical basis for the prevention as well as the treatment of AD.

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