摘要：

Objective: An appropriately designed sustained-release drug delivery system can be a major advancement towards solving problems concerning controlling the rate of drug delivery. Matrix tablets are an interesting option when developing an oral sustained release formulation. The present study focuses on oral sustained-release dosage forms and types of various polymers used to formulate matrix tablets of Zaltoprofen. Water soluble polymers such as polyvinylpyrrolidone may be used to increase the dissolution rates of poorly soluble drugs. Hydroxy Propyl MethylCellulose (HPMC) is cellulose ether which may be used as the basis for hydrophilic matrices for sustained release oral delivery. Polymer backbone of different grades of HPMC, microcrystalline cellulose in different combinations and ratios may be prepared for the treatment of post-trauma chronic inflammation.The aim of study is to develop a once daily sustained-release tablet dosage form of Zaltoprofen by optimizing the release profile of drug through varying the composition of polymers.Method: Sustained release tablets of Zaltoprofen were prepared by wet granulation method using water soluble polymers such as polyvinylpyrrolidone and different grades of cellulose ether like HPMC both intra and extragranularly. Polyvinylpyrrolidone (PVPK30) dissolved in isopropyl alcohol was used as the granulating agent. Various grades of microcrystalline cellulose (Avicel) were used in granules and matrices to control the release rate. Tablets were subjected to physicochemical characterization such as thickness, hardness, friability, weight uniformity, drug content, disintegration time, in vitro drug release, and stability studies. The kinetics of the dissolution process was studied by analyzing the dissolution data using five kinetic models, the zero-order equation, the first-order equation, the Higuchi square root equation, the Hixson-Crowell cube root law and Korsmeyer-Peppas equation. Result and Discussion: All formulations were found to be satisfactory when evaluated for thickness, weight uniformity, hardness, friability, drug content uniformity and in-vitro drug release. The in vitro drug release in optimized formulation Cl 1 was found to be 99.23 % in 24 hours. Cl 1 also showed satisfactory hardness (6.55+-0.0614 kg/cm2), friability (0.495%+- 1.258), drug content (99.47%+-0.0565) and weight variation (402.65+-0.3U8 mg). The analysis of the dissolution kinetic data shows that it follows the first order kinetics and the release process involves erosion / diffusion and an alteration in the surface area and diameter of the matrix system, as well as in the diffusion path length from the matrix drug load during the dissolution process.

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