ChemInform Abstract: Stereoselective Conjugate Addition Reactions to Phenylglycinol-Derived, Unsaturated Oxazolopiperidone Lactams
摘要：
Phenylglycinol-derived, unsaturated oxazolopiperidone lactams are extremely useful building blocks that undergo stereoselective conjugate addition reactions with organocuprates, enolates, and sulfur-stabilized anions, allowing the stereocontrolled introduction of substituents at the piperidine 4-position. The factors governing the exo- or endo-facial selectivity are discussed. The methodology can be used for the preparation of a variety of enantiopure piperidines, including pharmaceuticals, alkaloids precursors, piperidine-fused derivatives, as well as complex piperidine-containing natural products.
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DOI：
10.1002/chem.201100471
被引量：
年份：
2011
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