摘要：

PROBLEM TO BE SOLVED: To provide anti-CD22 antibodies and immunoconjugates thereof, and to provide methods of using anti-CD22 antibodies and immunoconjugates thereof.SOLUTION: The anti-CD22 antibodies are provided. A polynucleotide encoding the antibodies is provided. A vector comprising the polynucleotide is provided. A host cell comprising the vector is provided. A method of making an anti-CD22 antibody is provided, wherein the method comprises culturing the host cell under conditions suitable for expression of the polynucleotide encoding the antibody, and isolating the antibody. A B-cell proliferative disorder includes lymphoma, non-Hogkins lymphoma (NHL), aggressive NHL, relapsed aggressive NHL, relapsed indolent NHL, refractory NHL, refractory indolent NHL, chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma, leukemia, hairy cell leukemia (HCL), acute lymphocytic leukemia (ALL), and mantle cell lymphoma.

展开