PHARMACEUTICAL FORMULATION FOR THE PRODUCTION OF RAPIDLY DISINTERGRATING TABLETS
申请(专利)号:
US20080663036
申请日期:
2008-06-02
公开/公告号:
US2010173859A1
公开/公告日期:
2010-07-08
申请(专利权)人:
KARL KOLTER;MICHAEL SCHÖNHERR;SILKE GEBERT;KATHRIN MEYER-BÖHM;ANGELIKA MASCHKE
国省代号:
DE
摘要:
Pharmaceutical formulation in the form of compacts comprising <UnorderedList id="ul0001" listStyle="none"><ListItem id="ul0001-0001" number="0000">A) an agglomerated excipient content composed of <UnorderedList id="ul0002" listStyle="none"><ListItem id="ul0002-0001" number="0000">a1) 60-97% by weight of sugar or sugar alcohols,</ListItem><ListItem id="ul0002-0002" number="0000">a2) 1-25% by weight of a disintegrant, selected from the group consisting of crospovidone, croscarmellose, sodium carboxymethylstarch and L-hydroxypropylcellulose,</ListItem><ListItem id="ul0002-0003" number="0000">a3) 1-15% by weight of water-insoluble, film-forming polymers</ListItem><ListItem id="ul0002-0004" number="0000">a4) 0-15% by weight of water-soluble polymers and</ListItem><ListItem id="ul0002-0005" number="0000">a5) 0-15% by weight of further pharmaceutically customary excipients, the total of the components a1) to a5) being 100% by weight,</ListItem></UnorderedList></ListItem><ListItem id="ul0001-0002" number="0000">B) at least one active ingredient,</ListItem><ListItem id="ul0001-0003" number="0000">C) 0 to 10% by weight, based on the total amount of A) to D), of a lubricant or mold release agent, and</ListItem><ListItem id="ul0001-0004" number="0000">D), if appropriate, further pharmaceutical excipients.</ListItem></UnorderedList>
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