A family of mammalian Na+-dependent L-ascorbic acid transporters.

The facilitative sugar transporters of the GLUT type can transport the oxidized form of the vitamin, dehydroascorbic acid, but these transporters are unlikely...

H Tsukaguchi，T Tokui，B Mackenzie，... - 《Nature》

Dehydroascorbic acid, a blood–brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke

C does not penetrate the blood-brain barrier (BBB), its oxidized form, dehydroascorbic acid (DHA), enters the brain by means of facilitative transport....

J Huang，DB Agus，CJ Winfree，... - 《Proceedings of the National Academy of Sciences of the United States of America》

Genistein is a natural inhibitor of hexose and dehydroascorbic acid transport through the glucose transporter, GLUT1.

Genistein is a dietary-derived plant product that inhibits the activity of protein-tyrosine kinases. We show here that it is a potent inhibitor of the mamm...

JC Vera，AM Reyes，JG Carcamo，... - 《Journal of Biological Chemistry》

Human HL-60 myeloid leukemia cells transport dehydroascorbic acid via the glucose transporters and accumulate reduced ascorbic acid

HL-60 myeloid leukemic cells transport DHA through the facilitative hexose transporters (glucose transporters) and accumulate the reduced form of ascorbic acid...

JC Vera，CI Rivas，RH Zhang，... - 《Blood》

Vitamin C transporters

The dehydroascorbic acid transporters are members of the GLUT family of facilitative glucose transporters, of which at least three isoforms, GLUT1, GLUT3 ...

CI Rivas，F. A. Zúiga，A Salas-Burgos，... - 《Journal of Physiology & Biochemistry》

A Human Sodium-Dependent Vitamin C Transporter 2 Isoform Acts as a Dominant-Negative Inhibitor of Ascorbic Acid Transport

Vitamin C is transported as ascorbic acid (AA) through the sodium-ascorbate cotransporters (SVCT1 and-2) and as dehydroascorbic acid (DHA) through the faci...

E.，A.，Lutsenko，... - 《Molecular & Cellular Biology》

A Human Sodium-Dependent Vitamin C Transporter 2 Isoform Acts as a Dominant-Negative Inhibitor of Ascorbic Acid Transport.

acid (AA) through the sodium-ascorbate cotransporters (SVCT1 and-2) and as dehydroascorbic acid (DHA) through the facilitative glucose transporters. All...

Lutsenko，Eugene，A.，... - 《Molecular & Cellular Biology》

Method for increasing the concentration of ascorbic acid in brain tissue of a subject

This invention provides a method for increasing the ascorbic acid concentration in brain tissues of a subject which comprises administering to the subject an amount of dehydroascorbic acid effective to increase the concentration of ascor...

Agus, David B.，Vera, Juan C.，Golde, David W. - US