摘要：

diabetes exhibited a significantly higher risk of developing AD than age-matched subjects without T2DM (Leibson et al., 1997; Huang et al., 2014). Epidemiological studies have also examined the association between ApoE4 genotype and diabetes or insulin resistance, although the reports are controversial. For instance, a longitudinal study in Japanese-American men demonstrated that ApoE4 increases the risk of LOAD in individuals with T2DM (Peila et al., 2002). In contrast, population-based studies conducted by Marseglia et al. show an association between T2DM and risk of dementia only in ApoE4 non-carriers (Marseglia et al., 2016).

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