摘要：

Objective: To investigate the clinical characteristics,classification and pathological diagnosis of gastrointestinal B-cell lymphoma in Meizhou area. Methods: The clinical data,histological morphology and immunophenotype of 120 cases of primary gastrointestinal B-cell lymphoma were analyzed,including the age,gender,pathogenic sites,endoscopic manifestation or general morphology of surgical resection,and histological morphology. Immunohistochemistry( En Vision) was used for staining of CD20,CD2,CD5,Bcl2,Bcl6,CD10,Cyclin-D1,Mum-1 and Ki67. Results: The age of patients ranged from 2. 5 to 95 years old( median age of 52 years old),and the male to female ratio was 1. 2 : 1. The pathogenic sites frequently involved stomach( n = 61,50.83%),small intestine( n = 16,13.33%),ileocecal junction( n = 4,3.33%),cecum( n = 15,12. 50%),colon( n = 18,15%) and rectum( n = 6,5%). There were 27 cases of polyp/nodule/cauliflower-like endoscopic manifestation or surgical resection specimens( 22. 50%),18 of erosion( 15. 00%),and 75 of ulcer( 62. 50%).The pathological classification showed that there were 59 cases of diffuse large B-cell lymphoma( DLBCL)( 49.17%),43 of mucosa-associated lymphoid tissue extranodal marginal zone B-cell lymphoma( MALT)( 35.83%),10 of mantle cell lymphoma( MCL)( 8.33%),7 of Burkitt lymphoma( 5.83%),and 1 of Follicular lymphoma( FL)( 0.83%). All the cases expressed CD20,whereas did not express CD2,and expressed CD5,Bcl2,Bcl6,CD10,Cyclin-D1,Mum-1,and Ki67 in different degrees. Conclusion: The incidence of gastrointestinal B-cell lymphoma in male is slightly higher than that in female in Meizhou area( male to female ratio 1.2 : 1). There is no significant difference in the incidence rate of gastrointestinal diseases( 61 cases of stomach,59 cases of intestine). The intestinal B-cell lymphoma is most common in colon and cecum. DLBCL and MALT are the most common pathological classification,followed by MCL and Burkitt,and FL is very rare. MCL and FL mainly show polypoid masses. MALT mainly shows mucosal erosion and small ulcers. DLBCL mainly shows ulcers,with bigger ulcer volume compared with that of MALT. The general manifestation of the tumor is suggestive for the classification. According to the general manifestation,HE morphology and immunophenotype,most of the gastrointestinal B-cell lymphoma can be correctly diagnosed and classified.

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