Hazard Review of Bis(Chloromethyl)Ether (BCME)
摘要:
The toxic hazards of bis(chloromethyl)ether (BCME) are discussed. The findings of a variety of studies on BCME carcinogenicity in laboratory animals are summarized, including skin painting tests in Swiss-mice, injection tests in rats, subcutaneous injection tests in Swiss-mice, inhalation exposure tests in mice and Sprague-Dawley-rats. Occurrences of fibrosarcomas, fibromas, and lung adenomas in these animals are discussed. The results of a NIOSH survey of bronchial damage and lung cancer incidence among workers exposed to BCME at an anion exchange resin production factory are reviewed, including an increased incidence of abnormal sputum cytology and of lung cancer, particularly undifferentiated oat cell carcinoma. An increased incidence of lung cancer among workers exposed to chloromethyl-methyl-ether is discussed with respect to the probable concomitant exposure to BCME. Lung cancer deaths are also discussed among 8 of 68 workers from a facility where BCME exposures occurred. The formation of BCME from the reaction of hydrogen-chloride with formaldehyde is described.
展开
关键词:
Environmental surveys Industrial medicine Chlorine organic compounds Carcinogens Exposure Respiratory diseases
年份:
1973
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用!