摘要：

Vulvovaginal candidosis (VVC) is one of the most frequent causes of gynecological consultations. Therefore, the development of new antifungal therapies against VVC is relevant. In this context, the leaves ofFridericia chica(Bonpl.) L. G. Lohmann are considered a therapeutic alternative since they are traditionally used in VVC therapy. However, no scientific evidence has supported this use against fungal vaginal infections. Then, we aimed to characterize the antifungal effect of a hydroethanolic extract ofF. chicaleaves (HEFc) and evaluate the therapeutic potential of this extract in a VVC model. HEFc inhibited the growth ofC. albicans(256–1,204g/mL) andC. krusei(512g/mL) in vitro. HEFc inhibited yeast-to-hypha transition inC. albicansand has a low ability to induce resistance in this species. Intravaginal use of the HEFc at 50mg/mL causes mycological cure in animals with VVC after 6 days of treatment, similar to the effect observed for the commercial antifungal nystatin. These results support the traditional use ofF. chicaleaves as a topical therapeutic option to treat VVC.

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