Receptor editing in self-reactive bone marrow B cells. The Journal of Experimental Medicine. 1993. 177: 1009-1020
摘要：
The clonal selection theory (Talmage 1957; Burnet 1957) is the basis for much of the way we think about the immune system. Lymphocytes are seen as an inherently diverse population, containing cells that are born with differing specificities for antigens, upon which Darwinian antigenic selection subsequently eliminates unfit, autoreactive clones, and allows the survival and maturation of the...
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2011
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