A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins
摘要：
Tumor necrosis factor alpha and beta (TNF-alpha and TNF-beta) bind surface receptors on a variety of cell types to mediate a wide range of immunological responses, inflammatory reactions, and anti-tumor effects. A cDNA clone encoding an integral membrane protein of 461 amino acids was isolated from a human lung fibroblast library by direct expression screening with radiolabeled TNF-alpha. The encoded receptor was also able to bind TNF-beta. The predicted cysteine-rich extracellular domain has extensive sequence similarity with five proteins, including nerve growth factor receptor and a transcriptionally active open reading frame from Shope fibroma virus, and thus defines a family of receptors.
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关键词：
Humans Tumor Necrosis Factor-alpha Membrane Proteins Receptors, Cell Surface Receptors, Tumor Necrosis Factor DNA Blotting, Northern Cloning, Molecular Amino Acid Sequence Multigene Family
DOI：
10.1126/science.2160731
被引量：
年份：
1990
BMJ
Wiley
万方医学
Semantic Scholar
NCBI
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