Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability.
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39
摘要：
A pyridyl moiety was introduced into a previously developed series of farnesyltransferase inhibitors containing imidazole and cyanophenyl (such as ), resulting in potent inhibitors with improved pharmacokinetics.A pyridyl moiety was introduced into a previously developed series of farnesyltransferase inhibitors containing imidazole and cyanophenyl, resulting in potent inhibitors with improved pharmacokinetics.
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DOI：
10.1016/S0960-894X(03)00195-1
被引量：
年份：
2003
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