Analysis of homeodomain specificities allows the family-wide prediction of preferred recognition sites.
摘要：
We describe the comprehensive characterization ofhomeodomain DNA-binding specificities from a metazoan genome. The analysis of all 84 independent homeodomains from D. melanogaster reveals the breadth of DNA sequences that can be specified by this recognition motif. The majority of these factors can be organized into 11 different specificity groups, where the preferred recognition sequence between these groups can differ at up to four of the six core recognition positions. Analysis of the recognition motifs within these groups led to a catalog of common specificity determinants that may cooperate or compete to define the binding site preference. With these recognition principles, a homeodomain can be reengineered to create factors where its specificity is altered at the majority of recognition positions. This resource also allows prediction of homeodomain specificities from other organisms, which is demonstrated by the prediction and analysis of human homeodomain specificities.
展开
关键词：
DOI：
10.1016/j.cell.2008.05.023
被引量：
年份：
2008
Elsevier
国家科技图书文献中心
(权威机构)
Wiley
Semantic Scholar
Semantic Scholar
(全网免费下载)
查看更多
掌桥科研
万方医学
Ingenta
dx.doi.org
NCBI
Cell Press
Europe PMC
(全网免费下载)
Europe PMC
NCBI
(全网免费下载)
NCBI
ResearchGate
(全网免费下载)
ResearchGate
EBSCO
Citeseer
(全网免费下载)
core.ac.uk
(全网免费下载)
infona.pl
onAcademic
mendeley.com
science-open.com
pherobase.com
readcube.com
escholarship.umassmed.edu
emboj.embopress.org
genome.cshlp.org
pubfacts.com
yadda.icm.edu.pl
f1000.com
Semantic Scholar
(全网免费下载)
Europe PMC
(全网免费下载)
NCBI
(全网免费下载)
ResearchGate
(全网免费下载)
Citeseer
(全网免费下载)
core.ac.uk
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
来源期刊
引用走势
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
