Method for preparing submicron particle suspensions
申请(专利)号:
CA20012431705
申请日期:
2001-12-20
公开/公告号:
CA2431705A1
公开/公告日期:
2002-07-18
申请(专利权)人:
BAXTER INTERNATIONAL INC.
被引量:
摘要:
The present invention provides a method for preparing a suspension of a pharmaceutically-active compound, the solubility of which is greater in a water-miscible first organic solvent than in a second solvent which is aqueous. The process includes the steps of: (i) dissolving a first quantity of the pharmaceutically-active compound in the water-miscible first organic solvent to form a first solution; (ii) mixing the first solution with the second solvent to precipitate the pharmaceutically-active compound; and (iii) seeding the first solution or the second solvent or the pre-suspension.
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