Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal.

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阅读量：

137

作者：

K Lauber，E Bohn，SM Kr?Ber，YJ Xiao，SG Blumenthal，RK Lindemann，P Marini，C Wiedig，A Zobywalski，S Baksh

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摘要：

Efficient engulfment of the intact cell corpse is a critical end point of apoptosis, required to prevent secondary necrosis and inflammation. The presentation of "eat-me" signals on the dying cell is an important part of this process of recognition and engulfment by professional phagocytes. Here, we present evidence that apoptotic cells secrete chemotactic factor(s) that stimulate the attraction of monocytic cells and primary macrophages. The activation of caspase-3 in the apoptotic cell was found to be required for the release of this chemotactic factor(s). The putative chemoattractant was identified as the phospholipid, lysophosphatidylcholine. Further analysis showed that lysophosphatidylcholine was released from apoptotic cells due to the caspase-3 mediated activation of the calcium-independent phospholipase A 2. These data suggest that in addition to eat-me signals, apoptotic cells display attraction signals to ensure the efficient removal of apoptotic cells and prevent postapoptotic necrosis.

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关键词：

Cells Phagocytes Chemotactic Factors Migration 细胞吞噬细胞趋化因子

DOI：

10.1016/S0092-8674(03)00422-7

被引量：

1419

年份：

2003