PROCESS FOR FORMING MICROBUBBLES WITH HIGH OXYGEN CONTENT AND USES THEREOF
申请(专利)号:
WO2013US30392
申请日期:
2013-03-12
公开/公告号:
WO2013151682A1
公开/公告日期:
2013-10-10
申请(专利权)人:
CHILDREN'S MEDICAL CENTER CORPORATION
摘要:
Formulations containing a carrier and microbubbles encapsulating oxygen gas, and methods for making and using the formulations are described herein. The formulations are manufactured by a process which includes high shear homogenization. The resulting microbubble suspension may be centrifuged to further concentrate the microbubbles. The resulting concentrated LOM suspension preferably has an oxygen content ranging from 50 to 99% (vol). Prior to administration to a patient, the viscosity of the LOM suspension may be reduced to the desired viscosity, preferably similar to the viscosity of the patient's blood. The resulting LOM formulation typically has an oxygen concentration ranging from 65 to 80% (vol). The microbubbles are formed from one or more lipids, preferably one or more phospholipids, most preferably DSPC, and preferably also contain one or more stabilizing agents/excipients, preferably cholesterol.
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