New methodology toward chiral, non-racemic 2,5-cis-substituted piperidines via Suzuki cross-coupling
摘要：
1,2,3,4-Tetrahydropyridines were halogenated upon treatment with iodine to obtain the desired cross-coupling precursors. Diastereoselective hydrogenation of Suzuki cross-coupling adducts allowed the facile asymmetric synthesis of 2,5-cis-substituted piperidines in five steps from readily available pyridine.
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关键词：
ASYMMETRIC-SYNTHESIS STEREOSELECTIVE-SYNTHESIS ADRENERGIC ACTIVITY EXPEDIENT SYNTHESIS PYRIDINIUM SALTS MILD CONDITIONS DERIVATIVES ACIDS 1 4-DIHYDROPYRIDINES ADDITIONS
DOI：
10.1021/ol061415d
年份：
2006
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