Non-thrombogenic coating composition and methods for using same

阅读量:

41

申请(专利)号:

10/047118

申请日期:

01/14/2002

公开/公告号:

US20020115836

公开/公告日期:

08/22/2002

发明人:

R TsangS Osaki

展开

摘要:

The present invention provides an anti-thrombogenic and cellular-adhesion coating composition for blood-contacting surfaces. The coating comprises a covalent complex of from 1 to 30 hydrophobic silyl moieties of Formula I: 1 wherein R 1 is an C 1-18 alkyl or C 6-32 aryl group, each R 2 is independently selected from the group consisting of C 1-18 alkyl and C 6-32 aryl, R 3 is N or O, n is a number from 1 to 10, directly bound to a heparin molecule via covalent bonding, with an adhesive molecule directly bound to the heparin molecule. In one embodiment, the coating comprises benzyl-(1,2 dimethyl)disilyl heparin, wherein an adhesive molecule, such as fibronectin, is bound to the heparin.

展开

通过文献互助平台发起求助,成功后即可免费获取论文全文。

相似文献

参考文献

引证文献

辅助模式

0

引用

文献可以批量引用啦~
欢迎点我试用!

引用