Non-thrombogenic coating composition and methods for using same
申请(专利)号:
10/047118
申请日期:
01/14/2002
公开/公告号:
US20020115836
公开/公告日期:
08/22/2002
摘要:
The present invention provides an anti-thrombogenic and cellular-adhesion coating composition for blood-contacting surfaces. The coating comprises a covalent complex of from 1 to 30 hydrophobic silyl moieties of Formula I: 1 wherein R 1 is an C 1-18 alkyl or C 6-32 aryl group, each R 2 is independently selected from the group consisting of C 1-18 alkyl and C 6-32 aryl, R 3 is N or O, n is a number from 1 to 10, directly bound to a heparin molecule via covalent bonding, with an adhesive molecule directly bound to the heparin molecule. In one embodiment, the coating comprises benzyl-(1,2 dimethyl)disilyl heparin, wherein an adhesive molecule, such as fibronectin, is bound to the heparin.
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