摘要：

The effects ofpolyhomeotic (ph) mutants in imaginal cells have been studied in a clonal analysis. Clones of cells, homozygous forph, sort-out after a few divisions, probably as a consequence of modified cell affinities. The dorso-ventral margin of the winghas special characteristics that retard this phenomenon. The formation and exclusion of a clone of 8–16 cells affect the polarityof the wild-type neighbour cells and can provoke pattern triplications. The results suggest that a defect in intercellularcommunication prevents the wild-type cells from maintaining coordinated positional information. The cells react by regenerativegrowth, and reorganize into a new pattern. The pleiotropic phenotypes ofph mutants are explained according to a common hypothesis aboutph+ function.

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