Engineering antibodies for clinical applications
摘要：
Molecular engineering has contributed immensely to the clinical success of antibodies in recent years. The modular structure of antibodies has permitted their modification in numerous ways, to meet various clinical requirements. With the help of antibody engineering, it has been possible to modify the molecular size, pharmacokinetics, immunogenicity, binding affinity, specificity and effector function of antibodies. In addition, fusion proteins of antibodies with various proteins and peptides have yielded targeted biological modifiers, toxins and imaging agents. This review focuses on the recent trends in antibody engineering for improving their clinical utility.
展开
关键词：
compost thermophilic methane production Archaea Methanothermobactcr thermoautotrophicus Methanosarcina thermophila rice cluster
DOI：
10.1016/j.tibtech.2007.05.001
被引量：
年份：
2007
相似文献
参考文献
引证文献
引用走势
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
