Dynamic myosin phosphorylation regulates contractile pulses and tissue integrity during epithelial morphogenesis

Apical constriction is a cell shape change that promotes epithelial bending. Activation of nonmuscle myosin II (Myo-II) by kinases such as Rho-associated k...

CG Vasquez，M Tworoger，AC Martin - 《Journal of Cell Biology》

Dynamic myosin phosphorylation regulates contractile pulses and tissue integrity during epithelial morphogenesis

Apical constriction is a cell shape change that pr

Vasquez，G C.，Tworoger，... - 《Journal of Cell Biology》

Cortical Tension Allocates the First Inner Cells of the Mammalian Embryo

Summary Every cell in our body originates from the pluripotent inner mass of the embryo, yet it is unknown how biomechanical forces allocate inner cells in...

Chaminda R. Samarage，Melanie D. White，Yanina D. Álvarez，... - 《Developmental Cell》

Cortical Tension Allocates the First Inner Cells of the Mammalian Embryo

Summary Every cell in our body originates from the pluripotent inner mass of the embryo, yet it is unknown how biomechanical forces allocate inner cells in...

Chaminda R.，Samarage，Melanie D.，... - 《Developmental Cell》

Intracellular signalling and intercellular coupling coordinate heterogeneous contractile events to facilitate tissue folding

Cellular forces generated in the apical domain of epithelial cells reshape tissues. Recent studies highlighted an important role for dynamic actomyosin con...

S Xie，AC Martin - 《Nature Communications》

Regulation of tissue morphodynamics: an important role for actomyosin contractility

Forces arising from contractile actomyosin filaments help shape tissue form during morphogenesis. Developmental events that result from actomyosin contractility include tissue elongation, bending, budding, and collective migration. Here,...

MJ Siedlik，CM Nelson - 《Current Opinion in Genetics & Development》

From actomyosin oscillations to tissue‐level deformations

Pulsatile actomyosin contractility driving cell shape oscillations is a common feature of actomyosin networks present in a variety of tissues undergoing mo...

Gorfinkiel，Nicole - 《Developmental Dynamics》

Beyond Turing: mechanochemical pattern formation in biological tissues

During embryogenesis, chemical (morphogen) and mechanical patterns develop within tissues in a self-organized way. More than 60 years ago, Turing proposed ...

M Mercker，F Brinkmann，A Marciniak-Czochra，... - 《Biology Direct》

Tyrosine dephosphorylated cortactin downregulates contractility at the epithelial zonula adherens through SRGAP1

Contractile adherens junctions support cellcell adhesion, epithelial integrity, and morphogenesis. Much effort has been devoted to understanding how contra...

L Xuan，S Budnar，S Gupta，... - 《Nature Communications》

The organelle of differentiation in embryos: the cell state splitter

The cell state splitter is a membraneless organelle at the apical end of each epithelial cell in a developing embryo. It consists of a microfilament ring a...

NK Gordon，R Gordon - 《Theoretical Biology & Medical Modelling》