Palladium-catalyzed preparation of Weinreb amides from boronic acids and N-methyl-N-methoxycarbamoyl chloride.

阅读量:

52

作者:

R KrishnamoorthyQL SangCM ManleyRJ Herr

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摘要:

A simple protocol for the synthesis of Weinreb benzamides and alpha,beta-unsaturated Weinreb amides through a palladium-catalyzed cross-coupling reaction between organoboronic acids and N-methoxy-N-methylcarbamoyl chloride has been developed. The method is also applicable to the use of potassium organotrifluoroborates.

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DOI:

10.1002/chin.201023072

被引量:

78

年份:

2010

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