AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity
摘要：
Inhibition of PI3K-AKT signaling in tumors activates receptor tyrosine kinases Induction is due to relief of feedback inhibition of FOXO-dependent RNA expression AKT activates feedback via FOXO- and mTORC1-dependent pathways Inhibition of both AKT and induced RTKs is a promising therapeutic strategy
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关键词：
electron cryo-microscopy membrane protein structure membrane transport molecular model monovalent cation/proton antiporters
DOI：
10.1016/j.ccr.2010.10.031
被引量：
年份：
2011
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